Progesterone Receptor

NR3C3

Progesterone Receptor

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Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (159)
Recombinant Proteins (1)
Antibodies (2)

By Effects:	Inhibitors (12) Agonists (76) Ligands (5) Antagonists (22) Activators (10) Modulators (9)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0437

Progesterone	Agonist	99.79%
Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-13683

Mifepristone	Antagonist	99.88%
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay.

HY-B0469

Medroxyprogesterone acetate	Agonist	99.88%
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.

HY-B0084

Dienogest	Agonist	99.93%
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.

HY-B0891

17α-Hydroxyprogesterone	Agonist	99.63%
17α-Hydroxyprogesterone is a steroid hormone. 17α-Hydroxyprogesterone induces ovarian growth and yolk production in female crabs and increases blood pressure in sheep. 17α-Hydroxyprogesterone is mainly used in research related to crustacean reproduction and animal hypertension.

HY-N7424

4,7-Dihydroxycoumarin	Inhibitor	98.25%
4,7-Dihydroxycoumarin is an EGFR inhibitor, estrogen receptor inhibitor, and progesterone receptor inhibitor. 4,7-Dihydroxycoumarin against breast cancer cells with an IC₅₀ velue of 18.36 μg/mL. 4,7-Dihydroxycoumarin can be used for the research of breast cancer.

HY-117127

Clogestone acetate	Agonist
Clogestone acetate (AY-11440) is an orally active progesterone receptor agonist. Clogestone acetate reduces adrenal and ovarian weight, as well as serum and adrenocortical ketone levels in rats.

HY-B0742S1

Hydroxyprogesterone caproate-d₈	Ligand
Hydroxyprogesterone caproate-d₈ (17α-Hydroxyprogesterone hexanoate-d₈) is the deuterium labeled Hydroxyprogesterone caproate (HY-B0742). Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth.

HY-B0648

Medroxyprogesterone	Agonist	98.82%
Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469).

HY-N0437R

Progesterone (Standard)	Agonist
Progesterone (Standard) is the analytical standard of Progesterone. This product is intended for research and analytical applications. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-13676

Megestrol acetate	Inhibitor	99.69%
Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.

HY-B0111

Drospirenone	Agonist	98.45%
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .

HY-16508

Ulipristal acetate	Antagonist	99.89%
Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.

HY-B0742

Hydroxyprogesterone caproate	Ligand	99.29%
Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth.

HY-B0257A

Dydrogesterone	Agonist	99.88%
Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.

HY-B0554

Norethindrone	Agonist	99.21%
Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-13683R

Mifepristone (Standard)	Antagonist
Mifepristone (Standard) is the analytical standard of Mifepristone. This product is intended for research and analytical applications. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay.

HY-11028

PF-02413873	Antagonist	99.88%
PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a K_i of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.

HY-N0437S

Progesterone-d₉	Agonist	99.97%
Progesterone-d₉ is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-W011890

Cridanimod	Activator	99.80%
Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.

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Progesterone Receptor

Progesterone Receptor

Progesterone Receptor Related Products (159)

Recombinant Proteins (1)

Antibodies (2)

Progesterone Receptor Related Products (159):